COGNITION AND FUNCTIONALITY IN BREAST CANCER SURVIVORS UNDERGOING HORMONE THERAPY

Autores

  • Valéria Jardim Pires valeria.piresj@gmail.com
    Universidade Federal de Pelotas
  • Luana Siqueira Andrade andradelu94@gmail.com
    Universidade Federal de Pelotas
  • Ana Carolina Kanitz ana_kanitz@yahoo.com.br
    Universidade Federal do Rio Grande do Sul
  • Maria Laura Resem Brizio Gomes marialresem@hotmail.com
    Universidade Federal de Pelotas
  • Alessandra Menezes Morelle alemorelle@gmail.com
    Hospital Moinhos de Vento
  • Cristine Lima Alberton tinialberton@yahoo.com.br
    Universidade Federal de Pelotas
  • Stephanie Santana Pinto tetisantana@yahoo.com.br
    UFPel

DOI:

10.51283/rc.27.e14872

Palavras-chave:

Breast Neoplasms, Cognition, Physical Functional Performance

Resumo

The study aimed to describe the cognitive function and the functional capacity of breast cancer survivors who practice physical exercise. Eight women diagnosed with stages I-III breast cancer participated in this study. Cognitive tests were applied to assess overall cognitive function, processing speed, executive function, and attention. The women in the present study were 64.5 ± 4.8 years old, had a body mass index of 32.6 ± 5.4 kg.m-2, and had 10.0 ± 3.5 years of schooling. The results showed a preserved performance in the MSSE questionnaire and verbal fluency test in older women diagnosed with breast cancer four years ago, with obesity, who have been exercising for approximately 2.5 years. On the other hand, they presented a lower performance in the cognitive Trail Making Test and the functional tests than the normative values in the literature, indicating an impaired attention, processing speed, cognitive flexibility, and low functional capacity.

Referências

AHLES, Tim A. and collaborators. Cancer- and cancer treatment–associated cognitive change: an update on the state of the science. Journal of clinical oncology, v. 30, n. 30, p. 3675-386, 2012.

ARBUTHNOTT, Katherine D.; FRANK, Jonathan E. Executive control in set switching: Residual switch cost and task-set inhibition. Canadian journal of experimental psychology, v. 54, n. 1, p. 33-41, 2000.

AVILA, Renata and collaborators. Influence of education and depressive symptoms on cognitive function in the elderly. International psychogeriatrics, v. 21, n. 3, p. 560-567, 2009.

BAIL, Jennifer R. and collaborators. A home-based mentored vegetable gardening intervention demonstrates feasibility and improvements in physical activity and performance among breast cancer survivors. Cancer, v. 124, n. 16, p. 3427-3435, 2018.

BIGLIA, Nicoletta and collaborators. Objective and self-reported cognitive dysfunction in breast cancer women treated with chemotherapy: a prospective study. European journal of cancer care, v. 21, n. 4, p. 485-492, 2012.

BRAY, Victoria J. and collaborators. Evaluation of a web-based cognitive rehabilitation program in cancer survivors reporting cognitive symptoms after chemotherapy. Journal of clinical oncology, v. 35, n. 2, p. 217-225, 2017.

BROWN, Justin C. and collaborators. Aromatase inhibitor associated musculoskeletal symptoms are associated with reduced physical activity among breast cancer survivors. The breast journal, v. 20, n. 1, p. 22-28, 2014.

BRUCKI, Sonia M. D. and collaborators. Sugestões para o uso do mini-exame do estado mental no Brasil. Arquivos de neuropsiquiatria, v. 61, n. 3, p. 777-781, 2003.

BURSTEIN, Harold J. and collaborators. Adjuvant endocrine therapy for women with hormone receptor–positive breast cancer: american society of clinical oncology clinical practice guideline focused update. Journal of clinical oncology, v. 32, n. 21, p. 2255-2269, 2014.

CAMPANHOLO, Kenia R. and collaborators. Performance of an adult brazilian sample on the trail making test and stroop test. Dementia & neuropsychologia, v. 8, n. 1, p. 26-31, 2014.

CAMPBELL, Kristin L. and collaborators. Effect of aerobic exercise on cancer-associated cognitive impairment: a proof-of-concept RCT. Psycho-oncology, v. 27, n. 1, p. 53-60, 2018.

CAMPBELL, Kristin L. and collaborators. Exercise guidelines for cancer survivors: consensus statement from international multidisciplinary roundtable. Medicine and science in sports and exercise, v. 51, n. 11, p. 2375-2390, 2019.

CARVALHO, Guilherme A; CARAMELLI, Paulo. Normative data for middle- aged brazilians in verbal fluency (animals and FAS), trail making test (TMT) and clock drawing test (CDT). Dementia & neuropsychologia, v. 14, n. 1, p. 14-23, 2020.

CHEN, Xingu and collaborators. Impairment of the executive attention network in premenopausal women with hormone receptor-positive breast cancer treated with tamoxifen. Psychoneuroendocrinology, n. 75, p. 116-123, 2017.

COLLINS, Bárbara and collaborators. Cognitive effects of chemotherapy in post-menopausal breast cancer patients 1 year after treatment. Psychooncology, v. 18, n. 2, p. 134-143, 2009.

CORRIGAN, John D.; HINKELDEY, Nancy S. Relationships between parts A and B of the trail making test. Journal of clinical psychology, v. 43, n. 4, p. 402-409, 1987.

EHLERS, Diane K. and collaborators. Replacing sedentary time with physical activity or sleep: effects on cancer-related cognitive impairment in breast cancer survivors. BMC Cancer, v. 18, n. 1, p. 1-11, 2018.

ESTEVES, Cristiane S. and collaborators. Phonemic and semantic verbal fluency tasks: Normative data for elderly Brazilians. Psicologia: reflexao e crítica, v. 28, n. 2, p. 350-355, 2015.

FERREIRA, Arthur R. and collaborators. Differential impact of endocrine therapy and chemotherapy on quality of life of breast cancer survivors: a prospective patient-reported outcomes analysis. Annals of oncology, v. 30, n. 11, p. 1784-1795, 2019.

GAUDINO Elizabeth A. and collaborators. Construct validity in the trail making test: what makes Part B harder? Journal of clinical and experimental neuropsychology, v. 17, n. 4, p. 529-535, 1995.

INSTITUTO NACIONAL DE CÂNCER – INCA. Tipos de câncer: câncer de mama. 2020. Available in: <https://www.inca.gov.br/tipos-de-cancer/cancer-de-mama> Access: jul. 20, 2023.

JANELSINS, Michelle C. and collaborators. Prevalence, mechanisms, and management of cancer-related cognitive impairment. International review of psychiatry, v. 26, n. 1, p. 102-113, 2014.

LEZAK, Muriel D. and collaborators. Neuropsychological Assessment. 4. ed. New York, USA: Oxford University Press, 2004.

LINTERMANS, Anneleen and collaborators. A prospective assessment of musculoskeletal toxicity and loss of grip strength in breast cancer patients receiving adjuvant aromatase inhibitors and tamoxifen, and relation with BMI. Breast cancer research and treatment, v. 46, n. 1, p. 9-16, 2014.

LIU, Zeyu and collaborators. A study on the relationship between chemotherapy-induced cognitive impairment and age in patients with breast cancer. Journal of the balkan union of oncology, v. 23, n. 6, p. 1601-1605, 2018.

MACHADO, Thais H. and collaborators. Dados normativos de idosos saudáveis na prova de fluência verbal fonêmica - FAS. Dementia & neuropsychologia, v. 3, n. 1, p. 55-60, 2009.

MANDELBLATT, Jeanne S. and collaborators. cognitive effects of cancer and its treatments at the intersection of aging: what do we know; what do we need to know? Seminars in oncology, v. 40, n. 6, p. 709-725, 2013.

MAZO, Giovana Zarpellon and collaborators. Valores normativos da aptidão física para idosas brasileiras de 60 a 69 anos de idade. Revista brasileira medicina do esporte, v. 21, n. 4, p. 318-322, 2015.

MISHRA, Shiraz I. and collaborators. Exercise interventions on health-related quality of life for people with cancer during active treatment. The cochrane database of systematic reviews, v. 2012, n. 8, 2012.

NADJI, Mehrdad and collaborators. Immunohistochemistry of estrogen and progesterone receptors reconsidered. American journal of clinical pathology, v. 123, n. 1, p. 21-27, 2005.

OPASSO, Patricia Romano and collaborators. Phonemic verbal fluency task in adults with high-level literacy. Einstein, v. 14, n. 3, p. 398-402, 2016.

PARK, Denise C. and collaborators. Cerebral aging: integration of brain and behavioral models of cognitive function. Dialogues in clinical neuroscience, v. 3, n. 3, p. 151-165, 2001.

RIKLI,Roberta E.; JONES, Jessie C. Development and validation of a functional fitness test for community-residing older adults. Journal of aging and physical activity, v. 7, n. 2, p. 129-61, 1999.

ROBERTS, Kate and collaborators. Exercise therapies for preventing or treating aromatase inhibitor-induced musculoskeletal symptoms in early breast cancer. The cochrane database of systematic reviews, v. 1, n. 1, p. 1-56, 2020.

ROCK, Cheryl L. and collaborators. Nutrition and physical activity guidelines for cancer survivors. CA: a cancer journal for clinicians, v. 62, n. 4, p. 242-274, 2012.

SENHORINI, Maurien C. T. and collaborators. Phonemic Fluency in Portuguese-speaking Subjects in Brazil: Ranking of Letters. Journal of clinical and experimental neuropsychology, v. 28, n. 7, p. 1191-1200, 2006.

SERRA, Monica C. and collaborators. Resistance training reduces inflammation and fatigue and improves physical function in older breast cancer survivors. Menopause, v. 25, n. 2, p. 211-216, 2018.

SHILLING, Valerie and collaborators. The effects of adjuvant chemotherapy on cognition in women with breast cancer - preliminary results of an observational longitudinal study. The breast, v. 14, n. 2, p. 142-150, 2005.

SHILLING, Valerie and collaborators. The effects of hormone therapy on cognition in breast cancer. The journal of steroid biochemistry and molecular biology, v. 86, n. 3-5, p. 405-412, 2003.

SHILLING, Valerie and collaborators. The effects of oestrogens and anti-oestrogens on cognition. The journal of steroid biochemistry and molecular biology, v. 10, n. 6, p. 484-491, 2001.

STRAUSS Esther and collaborators. A compendium of neuropsychological tests: administration, norms and commentary. 3 ed. New York, USA: Oxford University Press, 2006.

SWEENEY, Carol and collaborators. Functional Limitations in Elderly Female Cancer Survivors. Journal of the national cancer institute, v. 98, n. 8, p. 521-529, 2006.

VILLALOBOS Dolores and collaborators. A systematic review of normative data for verbal fluency test in different languages. Neuropsychology review, 2022.

WAGNER, Lynne I. and collaborators. Measuring patient self-reported cognitive function: development of the functional assessment of cancer therapy-cognitive function instrument. The journal of supportive oncology, v. 7, n. 6, p. 32-39, 2009.

WOUTERS, Hans and collaborators. Trade-off preferences regarding adjuvant endocrine therapy among women with estrogen receptor-positive breast cancer. Annals of oncology: official journal of the european society for medical oncology, v. 24, n. 9, p. 2324-2329, 2013.

Downloads

Publicado

2023-08-09

Como Citar

Pires , V. J., Andrade, L. S., Kanitz, A. C., Gomes, M. L. R. B., Morelle , A. M., Alberton, C. L., & Pinto, S. S. (2023). COGNITION AND FUNCTIONALITY IN BREAST CANCER SURVIVORS UNDERGOING HORMONE THERAPY. Corpoconsciência, 27, e14872. https://doi.org/10.51283/rc.27.e14872

Edição

Seção

Seção Temática - ATIVIDADE FÍSICA E SAÚDE

Artigos mais lidos pelo mesmo(s) autor(es)