POSSIBLE HUMAN HEALTH RISKS OF NITRATES IN DRINKING WATER.: A CASE STUDY OF GROUNDWATER IN WANA DISTRICT, NORTHERN IRAQ.

ABBASNIA, A.; YOUSEFI, N.; MAHVI, A. H.; NABIZADEH, R.; RADFARD, M.; YOUSEFI, M.; ALIMOHAMMADI, M. Evaluation of groundwater quality using water quality index and its suitability for assessing water for drinking and irrigation purposes: Case study of Sistan and Baluchistan province (Iran). Human and Ecological Risk Assessment: An International Journal, v. 25, n.4, p. 988-1005, 2019. https://doi.org/10.1080/10807039.2018.1458596

ADIMALLA, N.; LI, P. Occurrence, health risks, and geochemical mechanisms of fluoride and nitrate in groundwater of the rock-dominant semi-arid region, Telangana State, India. Human and Ecological Risk Assessment: An International Journal, v. 25, n. 1-2, p. 81-103, 2019. https://doi.org/10.1080/10807039.2018.1480353

AHMED, G. A. H.; SANTURAKI, A. H.; MUKHTAR, M. Assessing the pollution indicator in groundwater in Hadejia metropolis, Jigawa state, Nigeria. International Journal of Chemistry Studies, v. 3, n. 2, p. 11-13, 2019.

AL-BHAR, B. M. A.; AL-SAFFAWI, A. Y. T. Health effect of nitrate concentration in the groundwater of Al-Manara village, north-east of Mosul city Iraq. Science Archives, v. 2, n. 3, p. 267-271. 2021. https://doi.org/10.13140/RG.2.2.16700.16005

AL-GADI, N. A. S.; AL-SAFFAWI, A. Y. T.; BÉJAOUI, M.; MAHMOUDI, E. Investigation of the potential risks to the human health risk of fluoride and nitrate via water consumption for some areas in Nineveh Governorate, Iraq. Acta Geophysica, p. 1-15, 2023. https://doi.org/10.1007/s116000-2201006-z

AL-HAMDANY, N. A. S.; AL-SHAKER, Y. M. S.; AL-SAFFAWI, A. Y. T. Application of nitrate pollution index (NPI) to evaluate the health safety of wells water for some quarters of the left side of Mosul city, Iraq. Biochemical and Cellular Archives, v. 20, n. 2, p. 6063-6068, 2020.

ALHARBI, T.; EL-SOROGY, A. S. Health Risk Assessment of Nitrate and Fluoride in the Groundwater of Central Saudi Arabia. Water, v. 15, n. 12, e2220, 2023. https://doi.org/10.3390/w15122220

AL-MASHHADANY, M. H. S. Valuation of groundwater contaminated with nitrates and human health risks (HHR) between villages of Sinjar and Tal Afar districts, Iraq. Pakistan Journal of Analytical & Environmental Chemistry, v. 23, n. 2, p. 277-287, 2022. http://doi.org/10.21743/pjaec/2022.12.10

AL-SAFFAWI, A. Y. T.; AWAD, M. H. Human health risk (HHR) of Nitrates in the groundwater of Abuwajnah village, Talafar district Iraq. World Journal of Pharmaceutical and Life Sciences, v. 6, n. 8, p. 13-19, 2020.

AL-SAWAF, F. D. Hydrogeology of South Sinjar Plain NW-Iraq. 211p. Doctoral Thesis – University of London, 1977. Available on: https://discovery.ucl.ac.uk/id/eprint/1349178/

AL-SINJARI, W. E.; AL-SAFFAWI, A. Y. T.; AL-TAEE, Y. A. J. Application of WQI Model to Assessment of water for irrigation and livestock drinking purpose: the case study, Groundwater quality of Gleewkhan village southeastern of Mosul city, Iraq. Journal of Engineering and Applied Sciences, v. 14, n. 9, p. 10706-10710, 2019.

ALYAN, Y. J. M. Subsurface geology of the Felville and wanh using geophysical data. 156p. Doctoral Thesis (unpublished) [Philosophy in Earth Sciences and Geophysics] - University of Mosul, College of Science, Mosul, 2010.

APHA_AWWA and WCPE. Standard method for examination of water and wastewater American public Health Association, 20th ed. Washington DC, USA. 1998.

APHA_AWWA and WCPE. Standard Method for Examination of water and wastewater American public Health Association, 23 ed; Washington DC, USA. 2017.

BREDA, S. G.; MATHIJS, K.; KISS, V.; KUHNLE, G. G.; VEER, B.; JONES, R. R.; SINHA, R.; WARD, M. H.; KOK, T. M. Impact of high drinking water nitrate levels on the endogenous formation of apparent N- nitroso compounds in combination with meat intake in healthy volunteers. Environmental Health, v. 18, p. 87-99, 2019. http://doi.org/10.1186/s12940-019-0525-z.

CHEN, F.; YAO, FL; MEI, G; SHANG, Y; XIONG, F; DING, Z. Groundwater quality and potential human health risk assessment for drinking and irrigation purposes: a case study in the Semiarid Region of North China. Water, v. 13, e783 2021. https://doi.org/10.3390/w13060783

COFFMAN, V. R.; JENSEN, A. S.; TRABJERG, B. B.; PEDERSEN, C. B.; HANSEN, B.; SIGSGAARD, T.; OLSEN, J.; SCHAUMBURG, I.; SCHULLEHNER, J.; PEDERSEN, M.; STAYNER, L. T. Prenatal exposure to nitrate from drinking water and markers of fetal growth restriction: A population-based study of nearly one million Danish-born children. Environmental Health Perspectives, v. 129, n. 2, e27002, 2021. https://doi.org/10. 1289/EHP73 31

DOUNA, B.K; YOUSEFI, H. Risk of nitrate residues in food products and drinking water. Asian Pacific Journal of Environment and Cancer, v. 6, n. 1, p. 69-79, 2023. https://doi.org/10.31557/APJEC.2023.6.1.69-79

GROUT, L.; CHAMBERS, T.; HALES, S.; PRICKETT, M.; BAKER, M. G.; WILSON, N. The potential human health hazard of nitrates in drinking water: a media discourse analysis in a high‑income country. Environmental Health, v. 22, e09, 2023. https://doi.org/10.1186/s12940-023-00960-5

JUNTAKUT, P.; HAACKER, E. M.; SNOW, D. D.; RAY, C. Risk and Cost Assessment of Nitrate Contamination in Domestic Wells. Water, v. 12, e428, 2020. https://doi.org/10.3390/w12020428

LI, D.; NISHI, S. K.; JOVANOVSKI, E.; ZURBAU, A.; KOMISHON, A.; MEJIA, S. B.; KHAN, T. A.; SIEVENPIPER, J. L.; MILICIC, D.; JENKINS, A.; VUKSAN, V. Repeated administration of inorganic nitrate on blood pressure and arterial stiffness: a systematic review and meta-analysis of randomized controlled trials. Journal of Hypertension, v. 38, n. p. 2122-2140, 2020. http://doi.org/10.1097/HJH.0000000000002524

LIN, L.; CLAIR, S.; GAMBLE, G. D.; CROWTHER, C. A.; DIXON, L.; BLOOMFIELD, F. H.; HARDING, J. E. Nitrate contamination in drinking water and adverse reproductive and birth outcomes: a systematic review and meta‑analysis. Scientific Reports, v. 13, e563. 2023. https://doi.org/10.1038/s41598-022-27345-x

MOTHFER, Z. A.; AL-SAFFAWI, A. Y. T. Probabilistic risk of nitrates to human health via drinking water: A case study of water supply for Dandan station and its quarters in Mosul city, Iraq. Journal of Advances in Environmental Health Research, 2023. https://doi.org/10.22102/JAEHR.2023.356398.1310

MUHIB, I.; ALI, M.; TAREQ, S. M.; RAHMAN, M. Nitrate Pollution in the Groundwater of Bangladesh: An Emerging Threat. Sustainability, v. 15, n. 10, e8188, 2023. https://doi.org/10.3390/su15108188

NUJIĆ, M.; HABUDA-STANIĆ, M. Nitrates and nitrites, metabolism and toxicity. Food in Health and Disease, v. 6, n. 2, p. 48-89. 2017.

PANNEERSELVAM, P.; KARUPPANNAN, S.; MUNIRAJ, K. Evaluation of drinking and irrigation suitability of groundwater with special emphasizing the health risk posed by nitrate contamination using nitrate pollution index (NPI) and human health risk assessment (HHRA). Human and Ecological Risk Assessment, v. 27, p. 1324-1348. 2020. https://doi.org/10.1080/10807039.2020.1833300

SHALYARI, N.; ALINEJAD, A.; HASHERNI, A. H.; RADFARD, M.; DEHGHANI, M. Health risk assessment of nitrate in groundwater resources of Iranshahr using Monte Carlo simulation and geographic information system (GIS). MethodsX, v. 6, p. 1812-1821, 2019.

SHERRIS, A. R.; BAIOCCHI, M.; FENDORF, S.; LUBY, S. P.; YANG, W.; SHAW, G. M. Nitrate in drinking water during pregnancy and spontaneous preterm birth: A retrospective within- other analysis in California. Environmental Health Perspectives, v. 129, n. 5, e57001, 2021. https://doi.org/10. 1289/EHP8205

STAYNER, L. T.; JENSEN, A. S.; SCHULLEHNER, J.; COFFMAN, V. R.; TRABJERG, B. B.; OLSEN, J.; HANSEN, B.; PEDERSEN, M.; PEDERSEN, C. B.; SIGSGAARD, T. Nitrate in drinking water and risk of birth defects: findings from a cohort study of over one million births in Denmark. The Lancet Regional Health – Europe, v. 14, e100286, 2022. https://doi.org/10.1016/j.lanepe.2021.100286

TEMKIN, A.; EVANS, S.; MANIDIS, T.; CAMPBELL, C.; NAIDENKO, O. V. Exposure-based assessment and economic valuation of adverse birth outcomes and cancer risk due to nitrate in United States drinking water. Environmental Research, v. 176, e108442, 2019. https://doi.org/10.1016/j.envres.2019.04.009

TOOLABI, A.; BONYADI, Z.; PAYDAR, M.; NAJAFPOOR, A. A.; RAMAVANDI, B. Spatial distribution, occurrence, and health risk assessment of nitrate, fluoride, and arsenic in Bam groundwater resource, Iran. Groundwater for Sustainable Development, v. 12, e100543, 2021. https://doi.org/10.1016/j.gsd.2020.100543

VERMEER, I. T. M.; PACHEN, F. D. M.; DALLINGA, J. W.; KLEINJANS, J. C. S.; MAANEN, M. S. Volatile N-Nitrosamine formation after intake of nitrate at the ADI Level in combination with an amine-rich diet. Environmental Health Perspectives, v. 106, n. 8, p. 459-463, 1998.

WHO_WORLD HEALTH ORGANIZATION. Guidelines for Drinking water Quality. 4th Edition. Switzerland: WHO, 2017. 631p.

YU, G.; WANG, J.; LIU, L.; LI, Y.; ZHANG, Y.; WANG, S. The analysis of groundwater nitrate pollution and health risk assessment in rural areas of Yantai, China. BMC Public Health, v. 20, p. 437-443, 2020. https://doi.org/10.1186/s12889-020-08583-y

ZHANGE, Q.; XU, P.; QIAM, H. Assessment of groundwater quality and Human Health risk (HHR), evaluation of nitrate in the central-western Guanhony basin. China. International Journal of Environmental Research and Public Health, v. 16, e4246, 2019. https://doi.org/10.3390/ijerph16214246

ZUCKERBRAUN, B. S.; GEORGE, P.; MARK, T.; GLADWIN, M. T. Nitrite in pulmonary arterial hypertension: therapeutic avenues in the setting of dysregulated arginine/nitric oxide synthase signalling. Cardiovascular Research, v. 89, n. 3, p. 542–552, 2017. https://doi.org/10.1093/cvr/cvq370