CERRADO DOMAIN FLORAL EXTRACTS AND ACETYLCHOLINESTERASE INHIBITION

Authors

DOI:

10.31413/nat.v11i2.14555

Keywords:

Cochlospermum, Tabebuia, inibição enzimática, acetilcolina, Myrciaria ssp, Jacaranda, Brosimum, sistema nervoso

Abstract

The Brazilian Cerrado has great floristic diversity that is still poorly studied on the effects and possible biological activities of human interest, such as the inhibition of acetylcholinesterase (AChE). Lyophilized floral extracts of different plant species produced between 2017-2022, kept at -12 °C, were used. The acetylcholinesterase inhibition method used was proposed by Ellman, modified by Miloševića and collaborators for a 96-well UV-Vis spectrophotometric microplate reader, using eserine as a standard positive control. On the 43 floral extracts on AChE inhibition C. regium, J. ulei, O. spectabilis, O. lancifolia and S. ferrugineus showed the highest inhibition rates > 50%. Floral extracts of A. humile, B. forficata, F. florida, H. stigonocarpa, H. courbaril, K. lathrophytum, M. guianensis, P. spruceanum, P. ovatum, Q. grandiflora, S. grandiflora, S. dysentericus, S. convallariodora, T. stenocarpa and Z. rhoifolium show no activity on AChE. The findings on the floral extracts in different solvents in this study, elucidate the need for future work in the separation of phytomolecules and determination of AChE inhibition activity, promoting them as new candidates for molecules in the development of new AChE inhibitor drugs.

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Published

2023-07-26

How to Cite

Pereira de Menezes Filho, A. C., Ventura, M. V. A., Alves, I., Castro, C. F. de S., Soares, F. A. L., & Teixeira, M. B. . (2023). CERRADO DOMAIN FLORAL EXTRACTS AND ACETYLCHOLINESTERASE INHIBITION . Nativa, 11(2), 207–211. https://doi.org/10.31413/nat.v11i2.14555

Issue

Vol. 11 No. 2 (2023)

Section

Bioprospecção e Biotecnologia / Bioprospecting and Biotechnology

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