EVALUATION OF THE REDOX STATE OF swiss MICE TREATED WITH Cnidoscolus urens AND SCOPOLAMINE

Antônio Carlos Alves de Sousa; Valfran  da Silva  Lima; Kaiany Fernanda da Silva; Helidi Schaiane da Silva; Anna Carolina  Vilela; Francielly Rieger Silveira; Guilherme Luz Emerick; Valéria Dornelles Gindri  Sinhorin

doi:10.31413/nat.v14i2.20745

Autores

Antônio Carlos Alves de Sousa antonio.sousa@ufmt.br
Institute of Health Sciences, Federal University of Mato Grosso, Sinop, MT, Brazil. https://orcid.org/0009-0004-7275-8942
Valfran da Silva Lima valfransl@hotmail.com
Institute of Health Sciences, Federal University of Mato Grosso, Sinop, MT, Brazil. https://orcid.org/0000-0002-6503-0257
Kaiany Fernanda da Silva kaianysilva1504@gmail.com
Institute of Health Sciences, Federal University of Mato Grosso, Sinop, MT, Brazil. https://orcid.org/0009-0008-3502-6661
Helidi Schaiane da Silva helidischaianedasilva@gmail.com
Institute of Health Sciences, Federal University of Mato Grosso, Sinop, MT, Brazil. https://orcid.org/0009-0009-0817-1350
Anna Carolina Vilela annavilela15@gmail.com
Institute of Health Sciences, Federal University of Mato Grosso, Sinop, MT, Brazil. https://orcid.org/0009-0003-3588-9540
Francielly Rieger Silveira franciellyrieger07@gmail.com
Institute of Health Sciences, Federal University of Mato Grosso, Sinop, MT, Brazil. https://orcid.org/0009-0009-0321-098X
Guilherme Luz Emerick guilherme.emerick@ufmt.br
Institute of Health Sciences, Federal University of Mato Grosso, Sinop, MT, Brazil. https://orcid.org/0000-0002-6206-3985
Valéria Dornelles Gindri Sinhorin valeria.sinhorin@ufmt.br
Institute of Chemistry, Federal University of Mato Grosso, Cuiabá, MT, Brazil. https://orcid.org/0000-0002-5070-0043

DOI:

https://doi.org/10.31413/nat.v14i2.20745

Palavras-chave:

oxidative stress, antioxidants, cansanção-branco

Resumo

Avaliação do estado redox de camundongos Swiss tratados com Cnidoscolus urens e escopolamina

RESUMO: A atividade antioxidante de uma espécie vegetal promissora, a Cnidoscolus urens (CU), pode ser investigada por meio de seus efeitos sobre o estado redox de um organismo exposto à escopolamina (ESC), um indutor de estresse oxidativo. Neste estudo, avaliou-se o efeito do extrato etanólico de CU sobre o estado redox de camundongos Swiss tratados com ESC. Os animais foram divididos em três grupos: controle (C; solução fisiológica), ESC (0,8 mg kg^-1) e ESC+CU (0,8 mg kg^-1 + 150 mg kg^-1). Foram analisados enzimas antioxidantes, marcadores não enzimáticos e indicadores de dano oxidativo no coração, no fígado e nos rins. No fígado e nos rins, não houve alterações nas atividades enzimáticas. No coração, a atividade da catalase aumentou apenas no grupo ESC. Os marcadores não enzimáticos não diferiram entre os grupos em nenhum dos tecidos. Em todos os tecidos, o marcador de dano lipídico no grupo ESC aumentou significativamente, mas somente no fígado houve redução nesse parâmetro com a coadministração de CU. Esses resultados indicam que a escopolamina teve impacto no estado redox desses tecidos, particularmente nas estruturas lipídicas, e que o extrato de C. urens não foi capaz de modular enzimas antioxidantes, mas teve efeito protetor contra a lipoperoxidação no tecido hepático.

Palavras-chave: estresse oxidativo; antioxidantes; cansanção-branco.

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