EVALUATION OF THE REDOX STATE OF swiss MICE TREATED WITH Cnidoscolus urens AND SCOPOLAMINE
DOI:
https://doi.org/10.31413/nat.v14i2.20745Palabras clave:
oxidative stress, scopolamine, antioxidants, cansanção-branco.Resumen
The antioxidant activity of a promising plant species, Cnidoscolus urens (CU), can be investigated through its effects on the redox state of an organism exposed to scopolamine (SCO), an inducer of oxidative stress. In this study, the impact of the ethanolic extract of CU on the redox state of Swiss mice treated with SCO was evaluated. The animals were divided into three groups: control (C; physiological solution), SCO (0.8 mg kg-1), and SCO+CU (0.8 mg kg-1 + 150 mg kg-1). Antioxidant enzymes, non-enzymatic markers, and indicators of oxidative damage were analyzed in the heart, liver, and kidneys. In the liver and kidneys, there were no changes in enzymatic activities. In the heart, catalase activity increased only in the SCO group. Non-enzymatic markers did not differ between groups in any tissue. In all tissues, the lipid damage marker in the SCO group increased significantly, but only in the liver was there a reduction in this parameter with the co-administration of CU. These results indicate that scopolamine had an impact on the redox state of these tissues, particularly on lipid structures, and the C. urens extract was unable to modulate antioxidant enzymes, but had a protective effect against lipid peroxidation in liver tissue.
Keywords: oxidative stress; antioxidants; cansanção-branco.
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